In addition, SSRIs carry a black box warning the most stringent from U.S. ![]() Symptoms include genital numbness, decreased sex drive (libido), erectile dysfunction, failure to become aroused or orgasm, pleasureless or weak orgasm, and premature ejaculation. Other effects can include weight gain, nausea, dizziness, insomnia, agitation or restlessness and headaches. Post-SSRI sexual dysfunction is under-recognised and can be debilitating both psychologically and physically. Most of the improvement (more than 50) occurred within the first 2 weeks and at low dose (100-200 mg/day). All sexual side effects improved in response to bupropion SR in both men and women with no differential effect on any one sexual side effect. A month later, EMA recommended that product information on all relevant antidepressants should be updated to reflect reports of long term sexual dysfunction after treatment. Global response rates were 46 for women and 75 for men. Sexual side effects in both genders Both men and women often experience the following as a result of antidepressants: weight gain nausea dizziness feelings of sluggishness Every person will. Nowadays there are some new antidepressants, which have more favourable side effect profiles. ![]() In May 2019, the pharmacovigilance risk assessment committee of the European Medicines Agency concluded that post-SSRI sexual dysfunction is a medical condition that can persist after discontinuation of SSRIs and serotonin-norepinephrine reuptake inhibitors (SNRIs). The problems can be even worse, because of the side effects of the antidepressants causing sexual dysfunction. Sexual difficulties after treatment with selective serotonin reuptake inhibitors (SSRIs) were first reported to regulators in 1991, but it was only in 2006 that these symptoms were formally characterised as a syndrome, now known as post-SSRI sexual dysfunction. An important iatrogenic condition, recognised by regulators
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